This course begins with a review of routes of administration, ADME (absorption, distribution, metabolism, & excretion), and the use of in vivo drug concentration-time data to determine key pharmacokinetic parameters, like volume of distribution, half-life and clearance. The course then emphasizes in vitro assays that allow rapid prediction of ADME and PK properties for evaluation of new compounds. The later stages of the course focus on how drug discovery teams study this PK/PD relationship, as well as dose size and frequency predictions which ultimately assist in selection of a compound for advancement into the clinic.
Pharmacokinetics
Pharmacokinetics
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15 项作业
授课语言：英语（English）
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本课程是 Drug Hunting: The Science of Making New Medicines 专项课程 专项课程的一部分
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Welcome, by the end of the course students will be able to: Summarize the key concepts of pharmacokinetics (PK), ADME (Absorption, Distribution, Metabolism, and Excretion), volume of distribution, half-life and clearance. Differentiate between different routes of drug administration and their impact on PK parameters. Define and describe the influence of transporters, plasma protein binding (PPB) and drug-drug interactions (DDIs) on the PK of a drug molecule. Explain how PK/PD relationships are derived and their importance for defining the anticipated human dose.
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学生评论
4.9
62 条评论
- 5 stars
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- 4 stars
8.06%
- 3 stars
1.61%
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OI
5
已于 Jul 14, 2024审阅
Amazing to-the-point course content, great citations to key articles and questions which are very helpful for permenance. I'm pleased as a medical doctor in drug research. Thanks for this course!
PV
5
已于 Sep 5, 2024审阅
Excellent at offering concepts of Pharmacokinetics
EK
4
已于 Aug 4, 2024审阅
Overall comprehensive basic content, clearly presented. Feedback on quizzes and assignments needs to be clearer and more informative in some cases.
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To access the course materials, assignments and to earn a Certificate, you will need to purchase the Certificate experience when you enroll in a course. You can try a Free Trial instead, or apply for Financial Aid. The course may offer 'Full Course, No Certificate' instead. This option lets you see all course materials, submit required assessments, and get a final grade. This also means that you will not be able to purchase a Certificate experience.
When you enroll in the course, you get access to all of the courses in the Specialization, and you earn a certificate when you complete the work. Your electronic Certificate will be added to your Accomplishments page - from there, you can print your Certificate or add it to your LinkedIn profile.
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